Abstract

Aim: To present the clinical features and therapeutic outcomes of Ocular Surface Squamous Neoplasia (OSSN) cases which were treated with surgery and adjunctive Mitomycine C (MMC).

Materials and Methods: The records of 38 eyes which were treated for OSSN were reviewed retrospectively. Patients in stages T1 and T2 were treated with ‘no touch’ technique complete excision, cryotherapy and adjunctive MMC. Two patients in stages T3 and T4 disease underwent exenteration.

Results: The pathological diagnoses were Conjunctival Intraepithelial Neoplasia (CIN) in 22, carcinoma in situ in 6, and invasive Squamous Cell Carcinoma (SCC) in 10 eyes. Tumor was primary in 28 and recurrent in 10 eyes. The rates of previously recurrent cases were highest in invasive SCC group and lowest in CIN group. No serious complications associated with MMC occurred. A recurrence was observed in only one eye out of 36 eyes in stages T1 or T2. One patient in stage T4 that was treated with subtotal exenteration presented with preauricular lymphadenopathy after 19 months.

Conclusion: Recurrences and treatment complications can still be seen today despite the new developments and facilities regarding the treatment of the OSSN. These recurrences and side effects impair the success rate by increasing morbidity. We recommend a complete excision followed by cryotherapy and routine postoperative adjuvant MMC application to decrease the risk of unsuccessful results.

Keywords: Conjunctiva; Squamous neoplasia; Ocular surface; Mitomycine C

Abbreviations: CIN: Conjunctival Intraepithelial Neoplasia; Ocular Surface Squamous Neoplasia; SCC: Squamous Cell Carcinoma; MMC: Mitomycine-C