Abstract

In the current study, an effort was made to formulate FDT of lomefloxacin HCl in an effort to improve patient compliance, offer a rapid start of action, increase solubility, and cover up its unpleasant taste. By complexing lomefloxacin HCl with Hydroxyl Propyl Cyclodextrin (HP-CD) via a solvent evaporation technique, taste masking and solubility were improved. The finished complex was then directly crushed into tablets utilizing various super disintegrants such as sodium starch glycolate, croscarmellose sodium, and polyplasdone XL-10 at concentrations of 1%, 1.5% and 2% while being sweetened with aspartame and lubricated with aerosol. The amount of medication released by FDT increases as the concentration of super disintegrants rises, and formulation F6-which contains 1.5% croscarmellose sodium and is thought to be the best formulation-releases the most medication-up to 100.68% in 45 minutes. Comparing the FDT of formulation (F6) to regular tablets, in vivo experiments demonstrated that the FDT had an excellent bioavailability. The HP-CD complex rapid dissolving tablet may be made utilizing several super disintegrants using the Direct Compression process, and it was discovered that it disintegrates in less than 2 minutes, resulting in a quicker effect and higher patient compliance.

Keywords: Super disintegrants; Lomefloxacin HCl; Croscarmellose sodium