Abstract

Metal ions, ligands and complexes have shown significant inhibitory activities against human ailments such as cancer, diabetes, bacterial and fungal infections. Good activity has been predominantly restricted to transition metal ions and complexes. It’s important that ligands are properly designed to have maximum activity on disease receptor cells. Furthermore, Structure Activity Relationship (SAR) of ligands and complexes can be modulated to ensure maximum activity against infected cells. However, synthetic drugs of ligands and metal complexes suffer from their side effects on receptors cells, toxicity and in some cases ardous synthesis and less environmental compatibility. This paper gives an overview of some current trends in ligands and metal complexes design and activity on human receptor cells.

Keywords: Metal ions; Ligands; Complexes; Cancer; Diabetes; Bacterial; Fungal effects; Structure activity relationship