Abstract

Candidiasis is one of the prevalent reproductive diseases in reproductive-aged women that can be fatal. The disease is caused by Candida spp. Lactobacillus spp. are gram-positive, facultative, non-sporulating and rod-shaped bacteria Generally Recognized as Safe (GRAS) and applied as probiotics. The antifungal activity of Lactobacilli is a controversial subject not well understood. Therefore, it would be interesting to study the antifungal activity of vaginal and uterine strains of Lactobacilli, and to screen for the superior Lactobacillus strains with higher lactic acid production, higher antibacterial as well as antifungal potential, and to improve them via the generation of the transformants that express and secrete the antifungal as well as antibacterial peptides such as metchnikowin.

Keywords:Bio-control; Candida; Metchnikowin; Probacteria; Peptide