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Abstract
Innovation in Tissue Engineering & Regenerative Medicine
Tissue Engineering for Reconstitution of Human Testicular Niche; One Step Closer to Fertility Preservation and Male Infertility Treatment
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Open or CloseMahdieh Javidpou1, Jalal Golzadeh1, Fatemeh Hajizadeh Tafti1 and Behrouz
Aflatoonian1-5*
1Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Department of Advanced Medical Sciences and Technologies, School of Paraedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
*Corresponding author:Behrouz Aflatoonian, Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, Email: b.aflatoonian@ssu.ac.ir
Submission: May 20, 2019; Published: July 09, 2019
ISSN: 2578-0336Volume1 Issue3
Abstract
Using various sources of stem cells together with different types of scaffolds provides a new route to investigate developmental process of male gametes, which until now was difficult to investigate in the human. In the future tissue engineering may be used for new regenerative medicine application in male infertility. This brief review outlines the progressive insights of this novel biomedical technology and its capabilities, how tissue engineering can mimic developmental processes In vitro and generate a three-dimensional niche for spermatogenesis for research and potential therapies.
Keywords: In vitro gametogenesis; Male infertility; Stem cells; Tissue engineering; Reproductive medicine
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