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Innovation in Tissue Engineering & Regenerative Medicine

Innovative Potential of Periodontal Ligament Cell Sheet Engineering in Functional Implant Therapy

  • Open or Close Isao Ishikawa1*, Kaoru Washio1, Kosei Yano1, Kengo Iwasaki2 and Yuka Tumanuma3

    1Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Japan

    1Institute of Dental Research, Osaka Dental University, Japan

    1Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan

    *Corresponding author:Isao Ishikawa, Institute of Advanced Biomedical Engineering and Science Tokyo Women`s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

Submission: October 03, 2018; Published: October 09, 2018

DOI: 10.31031/ITERM.2018.03.000507

ISSN: 2578-0336
Volume1 Issue2


Implant therapy is now one of the important dental treatments for reconstruction of oral function. Recently, increasing attention has been paid to several complications related to implant treatment, including inflammatory peri-implantitis. To solve these implant complications and restore missing functions of dental implants as compared to the natural tooth, several efforts have been performed to construct periodontal tissues around the implant, mimicking the anatomical structure of a natural tooth. In this mini review, we will first overview the previously reported studies to form periodontal tissues around the dental implant. Secondly, we will demonstrate our recent trial to construct a periodontium-based implant using cell sheet engineering. We succeeded in the formation of cementum- and periodontal ligament-like tissue around a titanium implant by transplanting a periodontal ligament cell sheet with a surface-modified implant in dogs. Finally, as future directions, some considerations that may be useful to obtain more stable periodontal apparatus structures around implants will be discussed, including artificial formation of the cementum on the titanium surface. This mini review aims to summarize previous trials and recent progress in the formation of implants with periodontium and to provide further insights for innovative implant therapy.

Keywords: Implant; Periodontal ligament; Cell sheet; Cementum

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