Abstract

Herein, we report a case of a 50-year-old female patient with advanced endometrioid carcinoma and several associated metabolic and endocrine disturbances. The patient was on hormonal contraception therapy with progestins and was referred because of clinical hyperandrogenism. An ultrasound examination revealed a thickened endometrium and the patient was sent for hysteroscopy, which reported endometrioid adenocarcinoma. In addition to known hypertension, dyslipidemia and type 2 diabetes, metabolic and hormonal laboratory test results showed hyperinsulinemia and hyperandrogenism. Bilateral oophorectomy was performed. The uterus could not be removed due to the advanced stage of disease. The ovaries revealed metastasis from endometrioid carcinoma on a background of bilateral stromal hyperthichotic. In this article, we discuss the role of hyperandrogenism and hyperinsulinemia in the development of this advanced cancer.

Keywords:Endometrial cancer; Hyperinsulinemia; Hyperandrogenism; Obesity; Oligomenorrhea