Abstract

Objective: To investigate the correlation between BMI & carotid atherosclerosis and bone metabolism in perimenopausal women.

Methods: Collected in March 2017 to July 2019 in shenzhen, southern medical university hospital health management center to accept physical examination of 89 patients with perimenopausal women had investigated and analyzed the clinical data were retrospectively according to whether the carotid atherosclerosis was divided into carotid sclerosis group and normal group, compared two groups of patients with clinical data, BMI, bone metabolism index, analysis of carotid atherosclerosis and bone metabolic index level of correlation.

Results: Among the 89 perimenopausal women, 25 had carotid atherosclerosis (the prevalence was 28.09%). The content of hypertension component ratio, diabetes component ratio, body mass index (BMI), carotid intima-media thickness (IMT), TG ,LDLc and parathyroid hormone (PTH) in the carotid atherosclerosis group was significantly higher than that in the normal group (P<0.05 or P<0.01). However, the levels of high-density lipoprotein cholesterol (HDL-c), 25-hydroxyvitamin D3[25(OH)D3], serum type I collagen cross-linked c-terminal peptide (CTX) and osteocalcin were all lower than the normal group (P<0.05 or P<0.01). Spearman correlation analysis showed that BMI, TG and PTH levels were positively correlated with IMT (r=5.513, 4.433, 5.264, P<0.05), while ldl-c, 25(OH)D3, CTX and osteocalcin levels were negatively correlated with IMT (r=-4.402, -4.508, -4.465, -4.406, P<0.05). Multivariate Logistic regression analysis showed that hypertension,diabetes, Overweight or obese, dyslipidemia, and osteocalcin declining were risk factors for cervical atherosclerosis in perimenopausal women (P<0.05).

Conclusion: Decreased osteocalcin level, increased TG and BMI, hypertension and diabetes are therisk factors for carotid atherosclerosis in perimenopausal women.

Keywords: Perimenopausal women; BMI; Carotid atherosclerosis; Bone metabolism; Osteocalcin