Abstract

Early diagnosis and therapy of neuroblastoma are critical which determine the prog nosis. Nuclear medicine plays a crucial role in theranostics and new radioactive agents are exploring in neuroblastoma. ⁶⁸Ga-FAPI-04 has become a valuable radiotracer to detect metabolic lesions clinically. To explore the possible application of ⁶⁸Ga-FAPI-04 in neuro-blastoma, we evaluated its uptake in neuroblastomabearing mice compared with ¹⁸F-FDG and extracted the xenografts for IHC assay. The PET-CT imaging showed significant up-take of tumor both in ⁶⁸Ga-FAPI-04 and ¹⁸F-FDG at 50min, and the tumor-tomuscle of ⁶⁸Ga-FAPI-04 (3.29±0.62) and ¹⁸F-FDG (3.25±0.32) are similar. The tumor-to-muscle was still high at 90min. IHC assay demonstrated positive FAP expression of neuroblastoma xenografts which consisted with the PET-CT imaging. ⁶⁸Ga-FAPI-04 showed high tissue contrast and prolonged uptake in neuroblastoma, and this result shows the viability of ⁶⁸Ga-FAPI-04 in neuroblastoma.

Keywords:Neuroblastoma; FAPI; FDG; ⁶⁸Ga; PET-CT