Abstract

Intraductal Papillary Mucinous Neoplasm (IPMN) is an intraductal mucin-producing neoplasm, with an increasing incidence. IPMNs may have clear malignant potential and exhibit a broad histological spectrum ranging from adenoma to invasive carcinoma. In contrast to the ductal adenocarcinoma, IPMNs have in general a better clinical prognosis. The clinical presentation of IPMN and Chronic Pancreatitis (CP) are often indistinguishable. Misdiagnosis of IPMN in patients with CP can lead to serious delays in the appropriate management. In patients with history of alcoholic CP, the possible presence of IPMN could not to be excluded. Due the high frequency of malignancy in IPMN, surgical approach should be considered. Assessment for potential IPMN is mandatory in patients with CP. All patients with CP must have a clinical assessment at least every 6 months, with abdominal US at least every year. In symptomatic patients with IPMN and severe abdominal pain, early pancreaticoduodenectomy must be strongly considered.