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Abstract
Global Journal of Endocrinological Metabolism
Evaluation of Serum Calcium and Alkaline Phosphatase Levels Among Sudanese Women Using Hormonal Contraceptives in Shendi Town, Suda
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Mohammed Salih MA1, Hussien AM1, Abdien Saeed A1, Almajed Altaher TA1, Mahjaf GM2 and Mohammed Hamad MN3*
1Faculty of Medical Laboratory Sciences, Department of Clinical Chemistry, Shendi University, Sudan
2Faculty of Medical Laboratory Sciences, Department of Medical Microbiology, Shendi University, Sudan
3Assistant Professor, Faculty of Medicine, Microbiology Department, Elsheikh Abdallah Elbadri University, Sudan
*Corresponding author: Mosab Nouraldein Mohammed Hamad, Assistant Professor, Faculty of Medicine, Microbiology Department, Elsheikh Abdallah Elbadri University, Sudan
Submission: September 01, 2025; Published: September 23, 2025
ISSN 2637-8019Volume3 Issue5
Abstract
Background: Contraceptives are methods used to prevent pregnancy. In recent years, attention has
grown regarding the potential alterations in metabolic processes and trace elements associated with
contraceptive use.
Objective: This study aimed to evaluate the serum calcium and Alka Line Phosphatase (ALP) levels
among Sudanese women using hormonal contraceptives.
Methodology: A case-control study was conducted in Shendi, Sudan (Feb 2023-Mar 2024). Eighty
women were enrolled (40 contraceptive users and 40 controls). Blood samples were analyzed for calcium
and ALP using the Mindray BA88A spectrophotometer. Data were analyzed using SPSS version 28.
Result: A significantly higher mean serum calcium level was observed in users (9.4mg/dl) than in nonusers
(8.2mg/dl, p=0.000). No significant difference was found in ALP levels (p=0.101). A weak positive
correlation was found between ALP and duration of use (r=0.335, p=0.034).
Conclusion: Hormonal contraceptive use appears to significantly increase serum calcium levels, with a
modest impact on ALP activity.
Keywords:Serum calcium; ALP; Contraceptives; Sudanese women; Metabolic impact
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