Abstract

The robust activity of the human immune system depends on adequate concentrations of D3 and 25(OH) D- substrates for generating calcitriol within immune cells. This is crucial for maintaining a robust immune system, overcoming infections, and preventing hyper-immune syndromes and autoimmunity. As described in this paper, the most cost-efficient way to curb infections-infectious epidemics, endemic states, or pandemics-is to maintain the population’s immunity via vitamin D sufficiency. Such naturally robust immune system can be maintained through safe daily sun exposure and/or vitamin D supplements, as described here. Approximately 75% of immune cell activities are dependent on vitamin D. While the dietary vitamin D intakes are too low, a balanced diet rich in vitamins (B and C), minerals/ions (e.g., magnesium, zinc, selenium, etc.), and antioxidants (mostly provided via colored green leaves and nuts), helps bolster the immune system. These micronutrients work synergistically in maintaining the functions of the immune system. Besides, when a robust natural immunity of the population is maintained, other than those traditional immunizations, there is no necessity for most vaccines. This would improve health, have fewer adverse effects, less hospitalization, and save costs to taxpayers. Despite ample evidence, no health agency has taken steps to achieve such, even though this approach would cost less than 0.1% of any patented COVID medications or vaccines. Adhering to discussed methods could significantly reduce hospitalization from sepsis/infections by several orders of magnitude and reduce the prevalence and healthcare costs associated with several common chronic diseases.

Keywords: 25(OH)D; 1,25(OH)₂D; Immune system; Mutations; Omicron; SARS-CoV-2