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Nasser Mikhail MD*
Department of Medicine, Endocrinology division, Olive-View-UCLA Medical Center, David- Geffen UCLA Medical School, USA
*Corresponding author: Nasser Mikhail MD*, Department of Medicine, Endocrinology division, Olive-View- UCLA Medical Center, David-Geffen UCLA Medical School, USA
Submission: January 06, 2023 Published: January 20, 2023
ISSN 2637-8019Volume3 Issue4
Background: Studies have shown that use of Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors
decreased serum uric acid concentrations.
Objective: To review the potential use of SGLT2 inhibitors for prevention of gout
Methods: Pub med search until January 5, 2023. Search terms included SGLT2 inhibitors, uric acid, gout,
treatment, diabetes. Randomized trials, meta-analysis, and guidelines are reviewed.
Results: SGLT2 inhibitors decreased serum uric acid levels by an average 0.55mg/dl (95% CI, 0.62 to
0.48, P<0.001) compared with placebo or comparator drugs. The magnitude of reduction in serum uric
acid with SGLT2 inhibitors was more pronounced with higher baseline serum uric acid levels and in
patients without type 2 diabetes. The decrease in serum uric acid concentrations occurred as early as 3
days after administration of SGLT2 inhibitor, was dose-independent, and was stable during the duration
of administration of SGLT2 inhibitors. Seven retrospective studies and 2 post-hoc analyses of large,
randomized trials showed that SGLT2 inhibitors reduced the risk of incident gout or the initiation of antigout
medications by 11-63%, whereas only one retrospective study did not report any significant effect.
Conclusion: SGLT2 inhibitors should be considered for gout prophylaxis in subjects with hyperuricemia.
Randomized trials are needed to define the optimum and cost-effective use of SGLT2 inhibitors for gout
prevention.
Keywords:SGLT2 inhibitors; Uric acid; Gout; Prevention; Type 2 diabetes; Heart failure
Ph.D in Agriculture from Faculty of Agriculture, Tohoku University
Research Professor, PhD, Holistic Research Institute
Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
Ph.D in Science from the Federal University of Alagoas, UFAL, Brazil
Assistant Professor in College of Architecture, Art and Design
Interim Dean, College of Education and Health Sciences, Director of Biomechanics Laboratory, Sport Science Innovation Program, Bridgewater State University
Professor of numerous training courses in Family Medicine
Assistant Professor, Department of Electronics and Computer Science
Emeritus Professor of Physics, Kadir Has University, Turkey
Wenzhou Medical University, China
Fooyin University, Taiwan
Saglik Bilimleri University, Turkey
Vincent Pol University, Poland
National Defence University of Malaysia, Malaysia
Dogus University, Turkey
Hope College, USA
Russian Academy of Sciences, Russia
Southern Cross University, Australia
Umm Al-Qura University, Saudi Arabia
City University of New York, USA
Khalifa University of Science & Technology, United Arab Emirates
Hebei Normal University, China
Alexandria University, Egypt
Indian Institute of Technology Kharagpur, India
Council for Agriculture Research and Analysis of Agri Economy (CREA), Italy
King Fahd University of Petroleum and Minerals, Saudi Arabia
King Abdulaziz University, Saudi Arabia
University of Oregon, USA
University of Edinburgh, Scotland
University of Tennessee, USA
Central University of Venezuela, Venezuela
Islamic Azad University Central Tehran Branch, Iran
Tourin University, Italy
Teaching & Public Speaking, Spain
Paeditric Hospital "Giovanni XXIII", Italy
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Universidad Miguel Hernández de Elche, Spain
Oral Roberts University, USA
Beijing Normal University, China
Howard University, USA
Edith Cowan University, Australia
Dubai Health Authority, UAE
University of Minnesota, USA
Indian Institute of Technology Kharagpur, India
Serhal Hospital, Lebanon
University of Malta, Malta
National Center for Global Health and Medicine, Japan
Molloy College, USA
Federal University of Piauí, Brazil
Krankenhaus Nordwest Hospital, Germany
Belgorod State University, Russia
Laval University, Canada
Cinvestav-Unidad Saltillo, Mexico
UPMC Hamot Neuroscience Institute, USA
Ramon Llull University, Spain
White Bear Associates, LLC, USA
Lehigh University, USA
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Institute of Solid State Physics of RAS, Russia
University of Buenos Aires, Argentina
Mansoura University, Egypt
King Saud University, Saudi Arabia
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