Incidence and Clinical Outline of Medical Comorbidities Among Old Schizophrenic Patients: An Initial Local Review

Perhaps, comorbidity between mental disorders and physical sicknesses is the rule rather than the exception [1]. It is estimated that although 25% of the adult population have mental health illness, 68% of them suffer from comorbid medical disease [2]. While readmission rates in psychiatric patients are high and we still lack the understanding its likely predictors, physical co-morbidity could be one of important risk factors for psychiatric readmission [2]. On the other hand, while the term ‘comorbidity’ is well-acknowledged in research and clinical settings, the idea remains complicated and methodological approaches are different [3]. So, there is now no agreement about the definition of comorbidity, which can be defined in several different methods [3]. In general, the term comorbidity has three meanings:

1. Indicating a medical sickness in a patient existing concurrently but independently with another condition.
2. Representing a medical disease in a patient that causes, is caused by, or is otherwise related to another ailment in the same patient.
3. Indicative of two or more medical sicknesses in a patient that exist at the same time,

regardless of their causative association [4]. In an inclusive trial of integrating different aspects of comorbidity, authors have combined different constructs and measures associated with the core concept of comorbidity. Hence, in this respect, four major distinctions were made according to the nature of the health condition, the relative importance of the co-occurring conditions, and the chronology of the conditions: comorbidity, multimorbidity, morbidity burden and patient’s complexity [5,6]. On the other hand, there is growing interest among physicians and scholars in the impact of comorbidity on a range of outcomes, such as mortality, health-related quality of life, patient's functioning, and health care utilization [7]. For instance, physical comorbidities, basic demographic data, and clinical variables have shown to much better foretell mortality than the risk of readmission [8]. Also, in patients with comorbidities, along with the higher risk of dying, a poorer functional status, quality of life, and a greater use of health services has been recounted [8]. These conclusions led to the inference that among patients with comorbidity, the focus of health care should not only be on one particular ailment, but, besides, on the pathology in other organs and on indicators for quality of care, such as complications of management, readmissions, treatment plans and compliance to generally accepted clinical recommendations [9,10]. Earlier studies on patients with serious mental ailment such as long-lasting schizophrenia, bipolar disorder, or protracted recurrent depression, have revealed that these patients have higher mortality rates than persons without serious mental disorder [11]. This variance is partially explained as being produced by increases in comorbid medical disorders in the mentally ill, frequently chronic diseases such as diabetes [12] and cardiovascular disease [13]. Alternatively, though there is an assumption that patients with serious mental sickness experience a shortened life expectancy due to increased mortality and few of these patients would survive until old age [14], there is now evidence that the numbers of these old mentally ill survivors is increasing [15,16]. As stated by a study, patients with serious mental disorder had significantly higher rates of medical emergency room visits and meaningfully longer lengths of medical hospitalizations than did the primary care control group [17], and for depressed aged persons with at least one chronic medical ailment, improvements in clinical management and harmonization of medical and mental health amenities could moderate the rate of utilization of services [18]. Furthermore, as said by another study on senior persons, readmission was most likely among persons with a primary diagnosis of schizophrenia, followed by bipolar disorder, depression, and substance abuse [19]. Likewise, comorbid severe mental illness in patients with diabetes is individually linked with greater risk of early medical or surgical re-hospitalization [20]. Besides, while health-risk behaviors (e.g., smoking, poor diet, and sedentary lifestyle) contribute to these poor outcomes, treatment with second generation antipsychotic drugs as well has been associated with poorer glycemic control among patients with diabetes [21]. Alternatively, patients with serious mental conditions appear to under-utilize primary care services [22] and consequently increase the risk of medical hospitalizations due to possibly avoidable complications [23]. Additionally, these patients may be at heightened risk of in-hospital adverse events, too, such as nosocomial infections and postoperative complications [24]. Nevertheless, another study had found no increased risk due to these comorbidities [25]. The aim of the present evaluation was to appraise the prevalence and physiognomies of medical comorbidities among a group of native elderly schizophrenic patients.

Razi psychiatric hospital in south of capital city of Tehran, as one of the largest and oldest public psychiatric hospitals in the Middle East, which has been established formally in 1917 and with a capacity around 1375 active beds, had been selected as the field of study in the present retrospective assessment. So, amongst its separate existent sections, chronic geriatric section of hospital with a capacity around 220 beds (110 for male and female aged patients, separately) had been designated as the specific field of investigation. Thus, for assessment, all chronic elderly schizophrenic patients (≥65 years old), as accessible sample, had been nominated and estimated with respect to registered checkups and comorbid medical conditions. Psychiatric diagnosis was principally based on ‘Diagnostic and Statistical Manual of Mental Disorders’, 5th edition (DSM-5) [26] and medical diagnosis was principally based on ‘International Statistical Classification of Diseases and Related Health Problems’, 10th Revision [27].

Statistical analysis

Descriptive statistics including means, standard deviations, and ranges for continuous variables and quantity or percent in each category for categorical variables were calculated for all characteristics. T-tests for continuous data and chi-square tests for categorical data were used to compare the necessary variables between genders or groups. Statistical significance, as well, had been defined as p value ≤0.05. MedCalc Statistical Software version 15.2 was used as statistical software tool for analysis.

According to the findings, the current assessment of elderly schizophrenic patients had been performed on one hundred and sixty-eight patients, including one hundred and one males and sixtyseven females, who had been hospitalized in the chronic section of the hospital for long-life. Mean age (±SD) of the patients were around 69.12±8.93 and 74.69±6.54 for male and female patients, respectively, which was significantly shorter for male patients [t=-4.383, p<0.00, CI 95% =-8.08,-3.06]. As said by results, nearly 89% (n=151) of aged patients had some kind of registered nonpsychiatric co-morbidity, usually between one to four problems, that required specific care by a primary care physician or specialist, and so had received related standard cares, visits and treatments, on a regular basis (Table 1).

Table 1: Prevalence of medical co-morbidities among elderly schizophrenic patients.

This amount of medical comorbidity was significantly higher in comparison with the local aged group of people with about 80% comorbidity (z= -3.2458, p<0.0012, CI 95%=-0.1761, -0.0435) [28]; (Table 2). Listed co-morbidities included diabetes, hypertension, falls, congestive heart failure, chronic obstructive pulmonary disease, osteoarthritis, cancer, coronary artery disease, liver disease, renal disease, stroke, thyroid disease, bed sore, aspiration/asphyxiation, seizure, hyponatremia, malnutrition, anemia, gastrointestinal bleeding, prostate enlargement, cataract, Parkinson disease and brain cyst (Table 1). Among them falls, hypertension and osteoarthritis were the most prevalent disorders with a percentage around 48.8%, 44.6% and 30.35%, respectively (Table 1).

Table 2: Prevalence of medical co-morbidities among elderly schizophrenic patients.

The next co-morbidities included malnutrition (30%), aspiration/asphyxiation (29.1%), prostate enlargement (27.7%), diabetes (23.2%), seizure (20.2%), renal disease (19.6%), bed sore (17.8%), hyponatremia (16%), coronary artery disease (14.8%), gastrointestinal disorder (8.33%), cataract (8.33%), liver disease (7.73%) and hypothyroidism (7.73%). The remaining comorbidities, including congestive heart failure, chronic obstructive pulmonary disease, cancer, stroke, anemia, Parkinson disease and brain cyst, were less than six percent, individually. As said by the findings, hypertension, renal disease and malnutrition were significantly more prevalent among male patients (p<0.0000, p<0.0045 and p< 0.0018, in turn) and hyponatremia, aspiration/ asphyxiation and seizure, were significantly more prevalent among female patients (p<0.0075, p<0.0000 and p<0.0009, one-to-one) (Table 3).

According to the findings and in comparison with the senior people of local people, while diabetes, renal diseases and malnutrition were significantly more frequent, coronary artery disease, gastrointestinal disorder and osteoarthritis were significantly less frequent among the present sample of chronic old schizophrenic patients (Table 3).

Table 3: Prevalence of medical co-morbidities among male and female elderly schizophrenics.

While the co-occurrence of mental and physical conditions is very common in clinical settings, the exact nature of relationship between them is very complex and hitherto not well understood [29]. So far, very little work has been done on medical comorbid disorders among patients with mental illnesses since comorbidity was rarely the main objective of studies [5]. Additionally, while comorbidity is generally associated with mortality, consequences of specific disease combinations depend on many issues [11]. It is clear that in elderly people, each body system undergoes changes, which occur over many years and are considered normal among senior people [10] However, these changes often place the elderly persons at high risk for the development of various diseases [15]. So, it is very important to differentiate normal from pathological alterations in order to prevent wrongly treatment of normal changes and failing to treat those that result from ailments [29].

Back to our discussion and with respect to clinical profile of medical comorbidity among senior schizophrenic patients, almost most of patients had some kind of registered non-psychiatric comorbidity that demanded specific attention by a primary care physician or specialist. Thus, in comparison with senior group of local people [28] a significantly higher proportion of comorbidity was evident among the present sample. Such a finding was in harmony with the outcomes of Brown et al. [12], Andrés et al. [5] and Vigod et al. [7] who believed that psychiatric patients have been widely reported to be at an increased risk of morbidity and mortality due to physical disorders and comorbidity between medical and mental disorders is the rule rather than the exception. But it was not in harmony with the conclusions of Daumit et al. [25], who had found no significant increased risk of morbidity or mortality associated with the presence of these comorbidities in severe mental patients.

Besides, among the listed comorbidities in current assessment, falls, hypertension and osteoarthritis were the most prevalent medical complications. These outcomes are partially consistent with the findings of Hendrie et al. [17], who had found hypertension, osteoarthritis and diabetes as the most prevalent medical comorbidities among aged mental patients. But in contrary to him, in the present assessment there was not any significant difference regarding prevalence of hypertension between the present sample of schizophrenics and senior group of local people. Besides, while his claim regarding higher prevalence of falls in comparison with the primary care controls was not approvable here, due to deficiency of reliable native recording, falls was meaningfully higher among our patients, in comparison with other recorded items. Anyhow, the impact of demographic variances should not be ignored, since his samples included more females, a variety of ethnic groups and outpatients from primary care clients, while our samples included more males, single ethnic group (Persians), and only inpatients. Also with respect to other major co-morbidities in the present assessment, like malnutrition, diabetes, seizure, renal disease, coronary artery disease, gastrointestinal disorder and hypothyroidism , our findings were to some extent in harmony with reports of Zubenko et al. [30], Zgueb et al. [31], Räsänen et al. [32], Gausset et al. [33], Lim et al. [34], Hewer et al. [35], Tabbane et al. [36], Abiodun et al. [37] and Kamara et al. [38], who had found, as a general rule, infections, lung, gastrointestinal, urogenital and cardiovascular diseases as the most prevalent medical comorbidities among severe mental patients; Because they were comparable only with respect to urogenital and cardiovascular diseases. Our results regarding the remaining rarer co-morbidities, like congestive heart failure, chronic obstructive pulmonary disease, cancer and stroke, again, were not coherent with the outcomes of Hendrie et al. [17] and Tabbane et al. [36]. Furthermore, since medical problems like, bed sore, aspiration/asphyxiation, seizure, hyponatremia and malnutrition, had not been pointed out or surveyed in the parallel studies, further assessment becomes difficult.

On the other hand, as said by the conclusions of the current evaluation, hypertension, renal disease and malnutrition were significantly more prevalent among male patients and hyponaremia, aspiration/asphyxiation and seizure, were meaningfully more prevalent among female patients, which may display a gender-based difference in this regard. While such a difference could depend partly on the route of care, and somewhat on biological grounds, it may perhaps offer facts for future studies, too. Likewise, in comparison with the local senior persons, diabetes, renal diseases and malnutrition were significantly more frequent among the present sample of chronic elderly schizophrenic patients, a finding which was again, unharmonious with the findings of Hendrie et al. [17]. Anyhow, while the impact of physical comorbidity on psychiatric readmission is still unsatisfactorily investigated problem, there is a growing interest among specialists and academics in the impact of physical comorbidity on a variety of outcomes in mental disorders, such as mortality, health-related quality of life and health care spending, which is noticeably higher for patients with comorbid disorders [10]. The comorbidity of mental and physical disorders is on the increase and as pointed out by Sartorius this topic is becoming a main challenge to medicine in the 21st Century [14].

Future research should address these topics with more indepth studies since new understandings in this field could lead to better prevention approaches to reduce psychiatric readmissions [15]. In this regard, teaching regarding the normal changes of aging should be the first intervention made with all aging adults to help them understand what is going on in their bodies. In addition, many interventions are available to compensate for these changes as well as to prevent the development of disease as a consequent of these interventions [29]. Short duration of assessment, small sample size, restriction of study to a single academic center and lack of parallel and concomitant control groups, were among the weaknesses of the present evaluation. Surely, further methodical research are needed to define proper care and interventions for this vulnerable group of patients.

While in comparison with senior group of local people the rate of medical co-morbidities, particularly diabetes, renal diseases and malnutrition, were significantly higher in chronic elderly schizophrenic patients, a significant difference, as well, was palpable regarding the interrelated items between male and female patients, which demands further methodical and gender-based studies to define proper care and interventions for this vulnerable group of patients.

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