Abstract

Ageing is a multidimensional process that transcends biological decline, encompassing emotional, symbolic and social dimensions that shape older adults’ quality of life. Serotonin, a key neuromodulator of mood, sleep, cognition and resilience, undergoes significant alterations throughout the ageing process, contributing to increased vulnerability and functional deterioration. The concept of serotoninomics, proposed by Jiménez-Trejo et al. Jiménez-Trejo et al. (2015,2024,2025), expands serotonin research towards a transdisciplinary framework that integrates biosynthesis, receptor dynamics, metabolism and the symbolic impact of serotonergic function on well-being. Recent studies have highlighted serotonin’s role in emotional resilience, particularly through its release in the habenula during socially and affectively charged contexts. Emerging evidence also points to the anti-aging gene Sirtuin 1 as a modulator of serotonergic biosynthesis and degradation, offering a molecular pathway to emotional and cellular longevity within the serotoninomics framework. Furthermore, age-related serotonergic decline may be addressed through integrative strategies that combine pharmacological interventions with non-pharmacological approaches such as music therapy, enriched environments, rituals, emotional validation and narrative legacy. These interventions not only enhance serotonergic activity but also strengthen autonomy and emotional clarity in geriatric care. This editorial proposal positions serotoninomics as both a clinical and symbolic model for redefining well-being in geriatric and gerontological practice, calling on professionals to curate serotonin-enhancing experiences rooted in human connection, dignity and cultural richness-reimagining longevity as a journey of emotional resonance and a sensitive legacy.

Keywords:Serotoninomics; Longevity; Habenula; Transdisciplinary neuroscience; Gerontological practice