Abstract

Theophylline toxicity is associated with a high risk of morbidity and mortality. The use of this molecule as a long-term broncho dilatator during asthma and chronic obstructive pulmonary disease remains quite common despite its narrow therapeutic margin and its related toxicity. The utilization patterns of Theophylline are not well described while noting a more frequent prescription in low-to-middle income countries. This exposes to an increased risk of intoxication and iatrogenic especially in the elderly who are more likely to develop clinical manifestations of Theophylline toxicity. Elderly patients are thus exposed to a higher risk of organ impairments and of drug interaction that may affect Theophylline clearance and lead to overdose. Otherwise, the management of these patients may be difficult due to more frequent comorbidities. We report the case of an elderly patient admitted to the emergency department in status epilepticus revealing severe chronic Theophylline toxicity.

Keywords: Theophylline; Intoxication; Chronic toxicity; Elderly; Iatrogenia; Emergency department

Abbreviations: COPD: Chronic Obstructive Pulmonary Disease; SVT: Supraventricular Tachycardia