1Department of Otorhinolaryngology, Sohag University, Egypt
2Department of Otorhinolaryngology, Fujita Health University School of Medicine, Japan
*Corresponding author: Mahmood A Hamed, Department of Otorhinolaryngology, Sohag Faculty of Medicine, East District, 82524, Sohag, Egypt
Submission: April 16, 2018;Published: May 01, 2018
ISSN: 2637-7780Volume1 Issue4
Cholesteatoma has the capacity for invasion, migration, change in differentiation, proliferation and recurrence which is quite similar to neo plasms; however, with no DNA affections, that rules out the hypothesis of being a neo plastic lesion [1,2]. Bone erosion is a fundamental biologic behavior of cholesteatoma that can cause serious complications. It is stimulated by a variety of factors that are still debated [3,4]. In the early 1962, the American Joint Committee  for Cancer Staging reported a standardized and widely accepted staging system for head and neck cancer. This allowed precise definition of the disease stage, planning treatment protocol and comparing outcome between different modalities and surgeons.