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Experiments in Rhinology & Otolaryngology

Regeneration of Traumatic Tympanic Membrane Perforations

  • Open or Close Zhengcai-Lou1* and Zihan Lou2

    1Department of Otorhinolaryngology, Wenzhou Medical University, China

    2Department of clinical medicine, Xinxiang medical university, China

    *Corresponding author: Zhengcai-lou, Department of Otorhinolaryngology, Wenzhou Medical University, 699 Jiangdong Road, Yiwu, Zhejiang 322000, China

Submission: September 09, 2017;Published: October 27, 2017

DOI: 10.31031/ERO.2017.01.000506

ISSN: 2637-7780
Volume1 Issue2


Objectives/Hypothesis: To analyse the therapeutic strategies for treating traumatic tympanic membrane perforations (TTMPs).

Study Design: Literature review

Methods: The relevant literature on methods for treating human TTMPs was reviewed. The advantages and disadvantages of each treatment were analysed.

Results: A total of 24 articles were included. Among them, eight reported the efficacy of growth factors, eight considered patches, and five only observed spontaneous healing. The remaining three studies focused on other treatment methods.

Conclusion: Although 80% of TTMPs tend to spontaneously heal within 3 months, large perforations usually fail to close. Topical application of growth factors or ofloxacin ear drops is simple, convenient, and inexpensive, and it can accelerate the healing of the eardrum and improve the closure rate of large TTMPs.

Keywords: Tympanic membrane perforation; Trauma; Patch; Growth factor; Closure

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