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Abstract
Advancements in Civil Engineering & Technology
Elevated Serum Delta Bilirubin Might Predict the Occurrence of Different Types of Jaundice with Special Reference to Chronicity of the Disease
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Open or CloseDr. Susruta Sen1, Partha Chakrabarti2, Sutirtha Chakraborty3, Ms. Indrani
Pathak1, Ms. Mandrita Das1 and Subhadip Choudhuri4*
1Department of Laboratory Services, The Calcutta Medical Research Institute, 7/2 Diamond Harbour Road, Kolkata 700027, India.
2Cell Biology and Physiology Division, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Kolkata, India.
3Department of Medical Biochemistry, Helse Fonna, Haugesund Hospital, Haugesund 5528, Norway.
4Department of Immunology, University of Texas Medical Branch, Galveston, Texas – 77550.
*Corresponding author: Subhadip Choudhuri, Department of Immunology, USA
Submission: February 20, 2020; Published: March 4, 2020
Volume2 Issue1 March, 2020
Abstract
Background: Present study was aimed to evaluate whether measurement of serum delta bilirubin and albumin level predict the chronicity and subsequent impaired hepatic function across the spectrum of different types of jaundice.
Methods: Serum total bilirubin, Delta bilirubin, albumin and GGT activity was measured by reflectance spectrophotometry.
Result: Decreased serum albumin was found in a significant inverse correlation with elevated delta bilirubin level among the subjects with obstructive (r=-0.4217, p=0.0023) and hepatic jaundice (r=-0.4214, p=0.0023).
Conclusion: Significant inverse relationship between elevated delta bilirubin and lower albumin level might indicate that the chronicity of the disease may be the predominant factor in hepatobiliary obstruction or hepatocellular injury that may worsen the pathology of obstructive or hepatic jaundice.
Keywords: Delta bilirubin; Albumin; Obstructive jaundice; Hepatic jaundice; Total bilirubin
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