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Determinations in Nanomedicine & Nanotechnology

Extract of Sweet cherries from Campania Region Possesses Antidiabetic Properties Modelling the Serum Insulin, Adiponectin, Leptin, and Resistin in Diabetic Rats

  • Open or CloseRosaria Sciarrillo1*, Vito Gallicchio2, Mariana Di Lorenzo3, Maria De Falco3,4,5 and Carmine Guarino1

    1Department of Science and Technologies, University of Sannio, Via De Sanctis sncI-82100 Benevento, Italy

    2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Via Contrada Amoretta, 83100 Avellino, Italy

    2Department of Biology, University of Naples “Federico II”, Naples, Italy

    2National Institute of Biostructures and Biosystems (INBB), Rome, Italy

    2Center for Studies on Bioinspired Agro-Environmental Technology (BAT Center), Portici, Italy

    *Corresponding author: Rosaria Sciarrillo, Department of Science and Technologies, University of Sannio, Via De Sanctis sncI-82100 Benevento, Italy

Submission: November 12, 2021;Published: November 23, 2021


The obesity-associated diseases, e.g. diabetes, are spread worldwide. The polyphenols have Interesting biological activities such as anti-inflammatory, antioxidant, anti-allergic, hepatoprotective, anti-thrombotic, antiviral and anti-carcinogenic activities. These constituent nutrients and bioactive food components are present in sweet cherry. Cherries are thought to have beneficial health properties, moreover, a diet with antioxidant-rich cherries significantly lowers the insulin, fasting glucose levels, key markers for the development of diabetes. In particular, within the Campania region (Italy), several sweet cherry local cultivars have been studied. Two accessions (Patanara and Mulegnana Nera) of autochthonous germplasm of Campania, which have significant differences in phenols, flavonoids and anthocyanins levels, are used to evaluate their extracts antioxidant effect in alloxan-induced diabetic rats. This study was designed to evaluate the consequence of antioxidant extracts from cherries on the blood glucose, cholesterol and triglycerides and serum insulin, leptin, adiponectin and resistin concentrations after 30 days of intragastrical administration of extracts of “Patanara” and “Mulegnana Nera” in alloxan-induced diabetic rats. Administration of “Patanara” and “Mulegnana Nera at a concentration of 200mg/kg body weight for 30 days, significantly reduced the levels of blood glucose and serum insulin, leptin and adiponectin levels. In conclusion, in this study, cherry antioxidant extract showed a beneficial effect on the diabetic rats.

Keywords:Sweet cherry; Antioxidant; Blood glucose; Diabetes; Leptin

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