1Laboratory of Applied Nanotechnology of Belousov, Ukraine
2Kharkov Medical Academy of Postgraduate Education, Ukraine
3State Institution, Institute of Hematology and Transfusiology of the National Academy of Medical Sciences of Ukraine
4Kharkov Regional Center of Blood Service, Ukraine
*Corresponding author: Andrey Belousov, Laboratory of Applied Nanotechnology of Belousov, Ukraine
Submission: October 12, 2021;Published: December 10, 2021
The problem of increasing the functional activity preservation of red blood cells is priority for the Blood
Service and clinical transfusiology. Taking into account the previously discovered unique properties
of magnetite nanoparticles, namely: non-specific modulation of metabolic processes, strengthening of
adaptive mechanisms of cellular organelles, acceleration of reparative processes at the level of membranes
and macromolecules, for the first time an attempt was made to use the upgraded saline solution of sodium
chloride (Nanotechnologically Upgraded Solution - NUS) as a resuspending of Erythrocyte-Containing
Components (ECC).
Objective: to improve the preservation of red blood cells containing donor blood components using
NUS for resuspending. To achieve this goal, the first stage of the study examined the effect of a New
Resuspending Solution (NUS) on lipoperoxidation, catalase activity, and red blood cell peroxidation
resistance in donor blood components containing red blood cells.
Object of research: Red blood cells from preservation blood of donors, which are intended for component
transfusion therapy. As a result of the study, the advantages of using NUS were established, namely: a
significant decrease in the levels of primary and secondary lipid peroxidation products in the first 15
days of observation, an increase in catalase activity and resistance of red blood cells to peroxidation in the
first stages of the study, inhibition of the shear reaction with neutral lipid peroxidation in the late stages
of observation.
Keywords: Nanomodified resuspending solution; Oxidative homeostasis; Peroxide resistance of red blood cells; Components containing red blood cells; Storage