Abstract

Aroyl-benzofurans are important heterocyclic compounds which displayed a wide range of biological activities and important structural motif of many pharmaceutical drugs. Most of the pharmaceutical drugs containing the aroyl-benzofuran structural core have severe side effects which limits its usage. Some of the drugs containing the aroyl-benzofuran structural core were withdrawn from the market due to its toxicity. So, there is a need for the development of new synthetic methods to functionalize these molecules which play a significant role in drug discovery program. The current review focuses on the C-H functionalization of 2-/3- aroyl-benzofurans which includes alkylation, arylation, phosphonylation and benzoylation which plays a crucial role in developing new anti-arrhythmic drugs.