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Abstract

Research in Pediatrics & Neonatology

Applications of Targeted Protein Degradation in Drug Discovery

  • Open or CloseXue H1#, Chen Y1# and Jin J1,2,3*

    1Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China

    2The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    3Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China

    #These authors contributed to this article equally

    *Corresponding author: Jin J, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China Email: jianping_jin@zju.edu.cn

Submission: April 04, 2021Published: May 06, 2021

ISSN : 2688-8394
Volume2 Issue4

DOI: 10.31031/ACSR.2020.02.000541

Abstract

Proteostasis is a process that controls protein abundance in living cells in order to maintain healthy proteome at both cell and organ levels. In eukaryotes, the ubiquitin-proteasome pathway and the lysosomal network are two main systems for this purpose. Since the first attempt was tried to design drugs using protein degradation principles in 2001, rapid progress has been made over the past 20 years. In this review article, we will summary a few approaches to design protein degradation drugs, including PROTACs, Homo-PROTACs, Opto-PROTACs, PHOTACs, CLIPTACs, ATTEC, AUTACs, as well as LYTACs, and briefly discuss their current progression.

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