Department of Galenics, University of Düsseldorf, Germany
*Corresponding author: Enno Christian Kurt Freye, MD, PhD, Department of Galenics, University of Düsseldorf, Germany
Submission: March 26, 2018; Published: April 05, 2018
ISSN: 2637-7802Volume2 Issue2
Objectives: Numerous CoQ10 preparations are on the market of which however, very little is known about their bioavailability and most of all there is no information regarding their efficacy on the mitochondrial electrical transport chain, being the prime driver for ATP synthesis.
Methods: Aside from own experimental results, data from other papers were taken to evaluate various other CoQ10 formulations and their ingredients regarding bioavailability and their efficacy on the synthesis of ATP formation within the mitochondria.
Results: Two Q10 formulations (Greenspeed® and Q10 Revolution®) do demonstrate a substantial increase in bioavailability, while at the same time also increase the formation of ATP within the mitochondria. Contrary, other formulations, in spite of their higher bioavailability, they however lack any kind of conclusive data demonstrating an increase in ATP formation, being a necessary constituent in the overall function of cells. Also, the touted higher efficacy of ubiquinol has never been demonstrated conclusively, and some of the ingredients within certain Q10 formulations, do contain toxic substances just to increase bioavailability however, having a toxic side effect on mitochondria.
Conclusion: So far only two CoQ10 preparations (Q10 Revolution® and Greenspeed®) on the European market have demonstrated to have a sufficiently high bioavailability while at the same time also showing a significant efficacy on cellular function in regard to ATP synthesis.
CoQ10; Q10 formulation; Bioavailability; ATP synthesis; Greenspeed®; Q10 revolution®