Abstract

Aim: Diabetes mellitus is a major issue throughout the world, every fifth person is affected with it and its associated problems. The aim of the study is to see the effect of Piper betel leaves powder in glucose and lipid levels and oxidative stress on albino rats. It can be beneficial to cure type 1 diabetes mellitus. So, that Piper betel leaves powder was taken from bench to bedside.

Method and materials Experimental method was used to analyze the therapeutic properties of betel leaves to investigate antidiabetic, lipidlowering and oxidative-stress reducing properties on albino rats. Each group contained six albino rats. Group A was control group which was fed with normal pallet rat’s diet. Alloxan and ammonium acetate were injected and high fat high cholesterol diet were orally fed to group B,C and D every day for 45 days. Piper betel dried leaves powder (150mg/kg body weight) was mixed into the diet and fed them daily. Statistical evaluation was done using mean, standard deviation and student’s‘t’ test. ‘P’ value less than 0.05 was considered statistically significant.

Results: The results showed a significant difference at various levels in antidiabetic, lipid-lowering and oxidative-stress reducing properties as well as increased level of protein, albumin and hemoglobin in albino rats. No toxicity was found in rats and no side effects were seen.

Conclusion: Piper betel dried leaves powder 150mg/kg/body weight can be used as potential pharmaceuticals in above-mentioned diseases. Overall Piper betel leaves are beneficial for disease and its associated problems.

Keywords: Piper betel; Hemoglobin; Alloxon; Oxidative stress; Diabetes