1Department of Pharmacy, JNTUK, India
2Department of Pharmaceutical Analysis and Quality Control, Shri Vishnu College of Pharmacy, India
3Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, India
*Corresponding author: DSNBK Prasanth, Research Scholar, Department of Pharmacy, JNTUK, Kakinada-533 003, Andhra Pradesh, India
Submission: December 15, 2017; Published: February 08, 2018
ISSN: 2637-7802Volume1 Issue2
The antipyrexia action of the methanol extract of A. pilosa had been explored utilizing the yeast evoked pyrexia procedure in rabbits. Paracetamol utilized as a positive control as well as negative control group acquired distilled water. Rectal temperatures of all rabbits had been documented instantly prior to the administration of the extract or vehicle or paracetamol as well as again at 30min period for 3h utilizing digital thermometer. The extract had been additionally phytochemically tested with regard to alkaloids, tannins, saponins, flavonoids, cardiac glycosides and phenols. At 400mg/kg dosage the extract revealed considerable decrease in yeast evoked raised temperature when compared with that of standard drug paracetamol where by the extract dose 200mg/kg had been less effective as compared to higher dose (p<0.05). Phytochemical testing demonstrated the existence of flavonoids, alkaloids, tannins, phenols, steroids, acid compounds, glycosides, amino acids, and proteins. This research confirmed that this methanol extract of A. pilosa at a dose of 400mg/kg owns considerable antipyretic outcome against the yeast-induced raised temperature. The antipyretic activity of A. pilosa extract could be due to its secondary metabolites, which probably consist of flavonoids like Rutin and Quercetin; sterols like β-Sitosterol. But, further phytochemical, as well as biological tests, are recommended to determine the other active chemical constituents accountable for the antipyretic activity.
Keywords: Argyreia pilosa; β-Sitosterol; Phytochemical analysis; Antipyretic; Rutin