Archives of Blood Transfusion & Disorders

Feature of Older Patients with Sickle Cell Disease in the Congo

Submission: September 18, 2017; Published: February 26, 2018

DOI: 10.31031/ABTD.2018.01.000509

ISSN: 2578-0239
Volume1 Issue2


Background: Despite the high mortality rate of patients with sickle cell disease during the childhood in Africa, their life expectancy is increasing. Consequently, the number of adults is growing. Hence, health providers need to be aware about their clinical and biological pattern.

Patients and Methods: We studied clinical and biological aspects of 47 patients with sickle cell disease and phenotype SS aged 40 years and over from 2011 to 2016.

Results: The mean age was 45 (range: 40-59) years. The female population was older with a mean age of 47 (p=0.05). 23 over 47 (48.9%) had a low monthly income. Older adults presented sever sickle cell related acute morbidity, with a number of 1.83 vasoocclusive crisis, 2 anemic crisis/ blood transfusions and 1.59 admission episodes per year blood transfusion procedure episodes. In our group 57.44% developed a chronic complication. The most frequent complications of older patients with sickle cell disease were elevated tricuspid regurgitant jet velocity on echocardiogram performed on 12/47 patients, avascular necrosis of the femoral head (19.14%) and persistent leg ulcer (8.51%). The mean hemoglobin rate was higher than the rest of the sickle cell disease population.

Conclusion: Sickle cell related acute morbidity is high in older patients. Chronic complications are more frequent in this group and elevated regurgitant jet velocity more common finding.

Keywords: Sickle cell; Congo; Older adults; Morbidity

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