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Advancements in Bioequivalence & Bioavailability

Critical Review on Thalassemia: Types, Symptoms and Treatment

  • Open or Close Hamidreza Shirzadfar*, Nasim Mokhtari

    Department of Biomedical Engineering, Sheikhbahaee University, Esfahan, Iran

    *Corresponding author: Dr. Hamidreza Shirzadfar, Department of Biomedical Engineering, Sheikhbahaee University, Esfahan, Iran

Submission: March 16, 2018; Published: April 20, 2018

ISSN 2640-9275
Volume1 Issue2

DOI: 10.31031/ABB.2018.01.000507


Thalassemia is a genetic blood disorder where the normal hemoglobin protein is produced in lower amounts than usual and share in common one feature. This means it is passed down from one or both parents through their genes. People with Thalassemia are not able to make enough normal hemoglobin, which causes severe anemia. Hemoglobin is found in red blood cells and carries oxygen to all parts of organ in the body; therefore organs are unable to function properly. There are 30 million carriers and approximately 10000 children are born with the disease every year in the world. There are two main classes of thalassemia, Different genes are affected for each type in your body. α and β, in which the α-globin and β-globin genes are involved. In this study we will generally explain thalassemia disease, types of it and its treatment.

Keywords: Thalassemia; Beta globin; Anemia; Blood transfusions; Deferoxamine; Globin gene; Deferiprone

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