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Abstract

Research in Medical & Engineering Sciences

Autologous Adipose-Derived Stromal Cells and PRF Extract for Spontaneous Intervertebral Disc Disease in Canine

  • Open or CloseSheng Chuan Lin1, I Wan Wang2, Tzong Fu Kuo3*, Yen Der HSWWU4, Shinn Chih Wu5 and KO Tung Chang4*

    1Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, Taiwan
    2Deng Chuan veterinary hospital, Taiwan
    3Department of Post Baccalaureate Veterinary Medicine, Asia University, Taiwan
    4Department of Biological Science and Technology, National Pingtung University of Science and Technology, Taiwan
    5Department of Animal Science and Technology, National Taiwan University, Taiwan

    *Corresponding author: Ko Tung Chang, Department of Biological Science and Technology, National Pingtung University of Science and Technology, NPUST, 91201, No.1, Sheufu Road, Neipu, Pingtung, Taiwan, Tel:+886 988859677; Fax: +886 8 7740584; kotungc@mail.npust.edu.tw
    Tzong Fu Kuo, Department of Post Baccalaureate Veterinary Medicine, Asia University, 500, Lioufeng Rd, Wufeng, Taichung 41354, Taiwan; Email:tzongfu@asia.edu.tw

Submission: February 22, 2018; Published: March 28, 2018

DOI: 10.31031/RMES.2018.04.000590

ISSN : 2576-8816
Volume4 Issue3

Abstract

The administration of autologous adipose-derived stromal cells (ADSC) and platelet-rich fibrin (PRF) extract by intra-venous injections was investigated as a treatment for canine intervertebral disc disease (IVDD). IVDD is a disease that can cause several symptoms in domestic dogs, ranging from pain to partial or complete paralysis. Five dogs suffered from IVDD that caused hind-legs paralysis with deep pain perception, were treated with autologous adipose-derived stromal cells, vascular fraction, and platelet-rich fibrin (PRF) extract. Autologous adipose-derived stromal stem cells (ADSC) were expected to ameliorate symptoms of IVDD due to its anti-inflammatory and cell regenerative action. Five sequential intravenous injections applied in one-week interval for five weeks improved condition of treated dogs judged by patients gait score and exercise pattern.

Keywords: Intervertebral disc disease; Adipose stromal stem cells; Platelet-rich fibrin; Stromal vascular fraction

Abbreviations: ADSC: Adipose Derived Stromal Cells; PRF: Platelet Rich Fibrin; IVDD: Intervertebral Disc Disease; MRI: Magnetic Resonance Imaging; CT: Computed Tomography; TGF-β: Transforming Growth Factor; VEGF: Vascular Endothelial Growth Factor; EGF: Epidermal Growth Factor; PDGF: Platelet Derivative Growth Factor

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