Abstract

The effects of Boscia senegalensis seed decoction a potential medicinal tree used traditionally on the treatment of diabetes was evaluated on serum lipid profile, glycemic and on the antioxidant, property was evaluated. This study was carried out at the laboratory of medicinal plants, health and galelic formulation of the Department of biological sciences, Faculty of Science, University of Ngaoundere, during the period started from the 1st April 2022 to the 1^st June 2022. To achieve our goals, our study was performed on male rats feeding simultaneously with Hyperlipidemic Diet (HD) and the extract of Boscia senegalensis for a period of 8 weeks. The measuring of fasting blood glucose and the measure of the lipid profile has been taken as the major marker of anti hyperlipidemia. At the beginning of the experiment the mean fasting blood glucose levels (83.7±1.9mg/mL) were not significantly different. In rat fed normal standard diet, the blood glucose was constant to 84.4±1.9mg/mL during the 7 weeks. It was found that Boscia senegalensis extract prevented simultaneously weight gain, increased blood sugar and increased blood lipids induced by consumption of a high fat diet the extract facilitates the elimination of lipids in the stool. In normal control group the levels of SOD, CAT and MDA were 6.6-9.7μU/mg, 39.2-44.0U/mg et1.1-13μM in plasma, liver and kidney respectively. Irrespective of the diet and drug administration regimes, stress parameters were lower in the blood and higher in the kidney. The extract decreasing blood levels of alanine aminotransferase (ALAT/ASAT) and serum creatinine, respectively. Boscia. senegalensis extract has an antihyperlipidemic properties and can be used in the treatment of vascular disorders including atherosclerosis.

Keywords:Boscia senegalensis; Antihyperlipidemic; Antihyperglycemic; Hyperlipidemic diet; Antioxidant