Mehmet Sarikaya* and Fatma Ozcan
Department of Pediatric Surgery, Selcuk University Medical Faculty, Alaeddin Keykubat Campus, Turkey
*Corresponding author:Mehmet Sarikaya, Department of Pediatric Surgery, Selcuk University Medical Faculty, Alaeddin Keykubat Campus, Turkey
Submission: May 15, 2022Published: May 23, 2022
ISSN 2581-0379 Volume5 Issue2
Aortic rapid deployment and sutureless bioprostheses have opened up a new avenue for treatment of complicated scenarios of aortic Infective Endocarditis (IE). These prostheses allow to technically simplify the intervention, as the aortic annulus manipulation is minimized, and to reduce both Cardiopulmonary Bypass (CPB) and Aortic Cross-Clamp (AXC) times. Nowadays, there is growing evidence to suggest that Sutureless Aortic Valve Replacement (SU-AVR) with the Perceval (Livanova) valve associates with shorter CPB and AXC times as well as with improved hemodynamics compared to conventional stented bioprostheses [1,2]. These features might be especially appealing when operating on patients undergoing complex procedures, as multivalvular surgery  or surgery for Infective Endocarditis (IE) . Patients with IE present with increased inflammatory and vasoactive mediators and, usually, with multiple comorbidities . In fact, prolonged AXC and CPB times have been associated with mortality and development of severe complications after valvular surgery for IE . Therefore, these patients will probably benefit most from shortening CPB and AXC, as well as the CPB-related inflammatory response. This study aims to analyze the short and mid-term clinical and hemodynamic outcomes of treating complicated native or prosthetic aortic IE with Perceval bioprostheses.
Pneumomediastinum, also known as “mediastinal emphysema”, is the presence of air in the mediastinum. Spontaneous Pneumomediastinum (SPM) is the presence of free air in the mediastinum without any causal factor such as trauma, mechanical ventilation, or iatrogenic injury . SPM is a rare entity that is often triggered by activities that cause acute changes in intrathoracic pressure, such as childbirth, strenuous exercise, vomiting, and coughing. It was first described in adults in 1939 and is much less common in children . Free air may leak from the ruptured alveoli into the pulmonary interstitium and then reach the mediastinum through the bronchovascular sheaths. It can migrate from the mediastinum to the neck, esophagus, submandibular space, and retropharyngeal space. Its incidence in the pediatric population ranges from 1/8000 to 1/15000 . There are two peak points for the disease, 6 months to 4 years old and 15 to 18 years old, and it is more common in male patients [4,5]. While tallness and thinness are known risk factors for spontaneous pneumothorax, no significant demographic features have been identified for SPM. There is no consensus or standardization for the treatment of the disease and the management of the disease process. In this study, we aimed to share our 10-year experience in the management of SPM cases in children.
The files of patients who were treated in our clinic for spontaneous pnomomediastinum between January 2013 and January 2023 were retrospectively reviewed. Fifteen pediatric patients whose diagnosis was confirmed by thorax tomography were included in the study. In our study, traumatic cases, cases that developed SPM during or during intubation, cases that underwent cervical or thoracic surgery, and cases with tracheostomy were excluded. In addition to the demographic data of the patients; The etiology of SPM, treatment process, admission complaints, clinical features, length of hospital stay, transition to oral feeding, imaging studies were examined in detail.
The mean age of the 15 SPM patients included in the study was 12±5.4, and nine (60%) were male and six (40%) were female. Demographic and clinical characteristics of the patients are given in (Table 1). Chest x-ray and then computed thorax tomography were performed in all cases (Figure 1). Etiology was asthma in three (20%) patients; pneumonia in five (33%) patients; Difficult swallowing was present in six (40%) patients. One (7%) patient developed SPM due to kuss-maul respiration resulting from diabetic keatoacidosis. Three of the five cases with pneumonia had COVID-19 pneumonia. Subcutaneous emphysema in 10 (66%) cases; six (40%) had difficulty swallowing; 10 (66%) had sore throat; Nine (60%) of them were found to have shortness of breath. While all of the cases were followed in at least 2nd level intensive care unit for an average of 3±1.2 days, the average hospital stay of the cases was 5±1.3 days. Esophagography was performed to exclude esophageal peroration in six. cases with swallowing difficulties. Contrast material leakage was not observed in the cases who underwent esophagography, but due to possible microperforation, they were followed up for 36±6 hours orally closed. We did not have a patient who had a chest tube or required surgery due to SPM. None of our patients died due to SPM.
Table 1.Demographic and clinical characteristics of patients.
Although SPM is very rare in children, it should be kept in mind in case of sudden onset chest pain and/or neck pain. The most common symptom described in the literature is chest pain . Unlike the literature, the most common symptom in our series was sore throat in 66%, followed by chest pain in 60% and shortness of breath at the same rate. SPM has been associated with many conditions and triggers, such as asthma exacerbation, pneumonia, severe coughing or vomiting, and other activities associated with the Valsalva maneuver . In our study, severe coughing attacks in six (40%) cases and difficulty swallowing in the same number of cases were prominent in the etiology. As in our series, no other study involving a high rate of difficult swallowing cases in etiology was found in the literature. In the esophagography taken for esophageal perforation, no finding suggestive of perforation was found in six cases with difficult swallowing in the etiology, but these cases were followed up for 36±6 hours orally closed due to the possibility of possible micro-perforation. Esophagoscopy was not performed on these patients because their esophagography was normal and their clinic was stable. We recommend that similar cases be followed up for at least 24 hours orally stop due to possible micro-perforation and associated mediastinitis.
After the Covid-19 pandemic, which started in Wuhan, China in December 2019 and affected the whole world, a large number of Covid-19-related SPM cases have been brought to the literature and this has been associated with a high risk of mortality [8,9]. In our series, Covid-19 pneumonia was present in three (20%) patients, but mortality did not develop in any of our cases. Agents such as H1N1, avian influenza A (H5N6), and human bocavirus have been implicated in the etiology of SPM [10-12]. One of the important etiological factors reported in the literature is asthma . In our study, SPM developed during an asthma attack in three (20%) patients. Kussmaul breathing developed in Diabetic Ketoacidosis (DKA) cases have also been blamed for the etiology of SPM. In a study in which 747 DKA cases were examined, SPM was detected in the thorax tomography of 10 of these cases . In our study, SPM developed due to Kussmaul respiration in a patient with DKA. Although chest x-ray is said to be sufficient for the diagnosis of the disease in most of the published SPM series, it may be insufficient for the diagnosis of mild cases . In our series, chest tomography was performed in all cases in order to confirm the diagnosis, determine the severity of the disease, and evaluate additional pathologies.
The disease is usually self-limiting with a conservative approach, if there is priority in treatment, treatment of the underlying disease, oxygen support, painkillers and anti-inflammatory drugs are used . In a review published by Gasser CR et al.  they stated that 25% of SPM cases were followed in the intensive care unit and the average hospital stay of the patients was four days . In our study, all of the cases were followed up in the intensive care unit for an average of 3±1.2 days due to possible complications and were hospitalized for an average of 5±1.3 days. The most comprehensive systematic review of the disease was published by Alemu BN et al.  and the mortality rate was reported as 5.6% in this review . The authors argue that mortal cases develop due to underlying diseases. No mortality was found in our series.
Cases with chest pain, sore throat, dysphagia, and dyspnea should be carefully examined for SPM. Although SPM is often selflimiting, it should be kept in mind that it can be mortal and patients should be followed up in intensive care conditions for the first 24-48 hours. Patients with sore throats and difficulty swallowing should be followed carefully for possible esophageal perforations and should not be rushed to switch to oral feeding.
© 2023 Mehmet Sarikaya. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.