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Significances of Bioengineering & Biosciences

How Schizophrenia Could be Caused by Cholera & Ferric Chloride Disease

Cusack Paul TE*

Department of BScE, Canada

*Corresponding author:Cusack Paul TE, Department of BScE, Canada

Submission: September 09, 2019 Published: October 09, 2019

DOI: 10.31031/SBB.2019.03.000571

ISSN 2637-8078
Volume3 Issue5


In this brief paper, we build upon other papers by this author that had two separate causes for schizophrenia. We combine the findings that point to Ferric Chloride and Cholera as the culprits as the underlying cause of schizophrenia.

Keywords: Schizophrenia; Ferric chloride disease; Dehydration; Alcohol


Cholera produces dehydration in its victims. I suspect that the survivors of cholera have their DNA damaged by the bacterium. The Adenine in DNA has a hydroxide ion an alcohol attached. It could be stripped off the cyclohexane to join to the Hydrogens from the acid (water is a weak acid) or the DNA itself. Perhaps the Iron replaces the hydrogen on the DNA molecule while Chlorine does the same for the hydroxide ion, the alcohol [1-4]. The damaged adenine has a chlorine and an iron in place of the Hydrogen and Hydroxide (Figure 1).

Figure 1:The damaged adenine has a chlorine and an iron in place of the hydrogen and hydroxide.

2FeCl2+2HOH → 2FeOH+2HCl+Cl2

Dehydration of Alcohol



My original thesis had Ferric Chloride (FeCl2) as the culprit causing schizophrenia [5,6]. Yet, cholera has a role too. This latest theory explains why iron laden water may lead to schizophrenia. It may also explain why schizophrenia is a northern hemisphere problem viz. Water supply systems using iron piping [7-9].


  1. Cusack P (2017) Schizophrenia and its causes: Ferric chloride (Cusack’s) disease. Men Health Fam Med 2: 1-2.
  2. Cusack P (2017) Mental illness and cholera. Men Health Fam Med 2: 1-2.
  3. Cusack P (2017) More on the robust solution for epidemiology: Nineteenth century in Quebec. J Biomet Biostat 8: 1-2.
  4. Cusack P (2017) Cholera, iron and mental illness in nineteenth century. J Biomet Biostat 8: 1-2.
  5. Cusack PTE (2017) LSD, caffeine, and cholera: Possible causes of schizophrenia. J Mol Genet Med 11(4): 296.
  6. Cusack PTE (2018) Chlorine, creosote and dementia. EC Psychology and Psychiatry 7(1): 11-12.
  7. Cusack PTE (2018) SZ and its cause: Ferric chloride disease. PRAS.
  8. Cusack PTE (2017) Dehydration: The cause of schizophrenia: Cholera, ferric chloride and caffeine. EC Psychology and Psychiatry 6(2): 89-90.
  9. Cusack PTE (2017) More on cholera and schizophrenia: In Mauritius. American Journal of Biometrics and Biostatistics 1(1): 1-2.

© 2019 Cusack Paul TE. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.

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