Department of Pediatrics, Taitung Mackay Memorial Hospital, Taiwan
*Corresponding author: Chang-Hsien Yu, Department of Pediatrics, Taitung Mackay Memorial Hospital, Taiwan
Submission: October 27, 2020; Published: November 24, 2020
ISSN: 2577-9200 Volume5 Issue1
Abbreviation Persistent Pulmonary Hypertension of Newborn (PPHN);Coarctation of Aorta (CoA);Patent Ductus of Arteriosus (PDA).
A male newborn was born to a 18y/o mother at gestational age of 38weeks, birth weight 3295gm via emergent Cesarean section with the indication of fetal distress. The mother was diagnosed with type II DM and pregnancy-induced hypertension. Aspirin was given by a family doctor for prevention of preeclampsia during gestational age of 29 to 36 weeks. After birth, the baby presented persistent desaturation (SpO2 77-85%) and severe respiratory acidosis despite of resuscitation. CXR revealed cardiomegaly. Echocardiography showed remarkable dilatation of right ventricle and a huge Patent Ductus of Arteriosus (PDA) with almost right-toleft shunt. Persistent Pulmonary Hypertension of Newborn (PPHN) was diagnosed. However, the isthmus of aorta was restricted (the narrowest diameter was 0.220cm) (Figure 1).
Coarctation of aorta was impressed as well. Milrinone and prostaglandin E1 were dripped for right-ventricle dysfunction and to keep the PDA from closure. We hold the use of inhaled nitric oxide because of the suspected CoA. On day 2, his vital signs became more stable and the following echocardiogram showed the diameter of the isthmus of aorta was 0.318cm. According the clinic manifestation, we asserted it might be not a true coarctation of aorta. Targeting the treatment of pulmonary hypertension, we found that the coarctation of aorta disappeared gradually. On day 4, the shunt of his PDA became almost left-to-right and the diameter of the isthmus of aorta was 0.507cm (Figure 2). We discontinued milrinone and prostaglandin E1. Mechanical ventilation was removed smoothly.
Though PPHN and severe CoA share the same picture of a large PDA with right-to-left shunt, these two diseases have difference clinical manifestation and onset of symptoms and could be differentiated easily. However, in our case, there was a combined presentation, which would increase the difficulty of management. The “CoA” in our patient was proved to be transient. It was not clear what the association between PPHN and CoA was. For women at high-risk of developing preeclampsia, low-dose aspirin is used to reduce the incidence of preeclampsia .
The use of aspirin is safest in the second trimester before 20 weeks. After 30 weeks, there were concerns about prenatal constriction of the ductus arteriosus and PPHN . A possible hypothesis of our case was that aspirin constricted the ductus arteriosus as well as the isthmus of aorta in fetus. After birth, PPHN resulted in the decreased cardiac output of left ventricle, which might augment the appearance of the transient CoA. This theory is evidenced that the transient CoA was improved after resolution of PPHN. In such condition, observation and support care could be used to exclude the real CoA.
© 2020 Chang-Hsien Yu. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.