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Abstract
Research in Pediatrics & Neonatology
Perioperative Goal Directed Fluid and Hemodynamic Therapy with Echocardiography in Children: A Study Protocol
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Open or CloseKumba C1,2,3,4* and Tréluyer JM2,3
1 Department of Pediatric Anesthesia and Critical Care, Necker Enfants Malades University Hospital Assistance Publique Hôpitaux de Paris, Université de Paris, France
2 Department of Clinical Research and Pharmacology, Necker Enfants Malades University Hospital Assistance Publique Hôpitaux de Paris, Université d Paris, France
3 EA 7323 Pharmacologie et Evaluation des Thérapeutiques Chez L‘Enfant et La Femme Enceinte, Université de Paris, Paris, France
4 Ecole Doctorale 563 Médicaments-Toxicologie-Chimie-Imageries (MTCI), Université de Paris, France
*Corresponding author: Claudine Kumba, Department of Pediatric Anesthesia and Critical Care, Necker Enfants Malades University Hospital Assistance Publique Hôpitaux de Paris, Université de Paris, France
Submission: December 28, 2019; Published: January 08, 2020
ISSN : 2576-9200Volume4 Issue2
Abstract
Background: Echocardiography is a tool widely used in diagnostic and interventional cardiology. There are no pediatric studies concerning the impact of perioperative goal directed fluid and hemodynamic therapy with echocardiography on postoperative outcome. This study protocol was designed to determine the impact of perioperative goal directed fluid and hemodynamic therapy (PGDFHT) with echocardiography on postoperative outcome in children.
Objective The primary objective of this study protocol is to describe the trial which is in development and which will determine the impact of PGDFHT with echocardiography on postoperative outcome in terms of morbidity. The secondary objectives of the study are to clarify the impact of PGDFHT with echocardiography on postoperative length of stay in the intensive care unit, length of invasive or noninvasive mechanical ventilation and postoperative length of hospital stay.
Methods:Patients will be randomized in two groups, one control and one experimental group. The study will be single blinded, mono or multicentric.
Patients: Patients aged less than 18 years old admitted for surgery. Statistical analysis will be realized with XLSTAT 2018.3 or plus software.
Result and Conclusion: This trial protocol was designed to describe the study in progress and development which will determine the impact of perioperative goal directed fluid and hemodynamic therapy with echocardiography on postoperative outcome in pediatric patients admitted for surgery.
Keywords: Children; Echocardiography; Perioperative goal directed fluid hemodynamic therapy; Postoperative outcome
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