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Research in Pediatrics & Neonatology

Benign Transient Hyperphosphatasemia

  • Open or CloseCrudo DF1*, Linton JM2 and Sebesta MR2

    1 Department of Pediatrics Section on Pediatric Endocrinology, Wake Forest University, USA

    2 Department of Pediatrics Section on General Pediatrics, Adolescent Medicine, and Rheumatology, Wake Forest University, USA

    *Corresponding author: David F Crudo, Department of Pediatrics Section on Pediatric Endocrinology, Wake Forest University School of Medicine, USA

Submission: November 19, 2019; Published: November 26, 2019

ISSN : 2576-9200
Volume4 Issue1


Benign transient hyperphosphatasemia is an idiopathic condition characterized by a temporary elevation of alkaline phosphatase of up to 5 times greater than the upper limit of normal in the absence of bone or hepatobiliary disease. It is typically seen in young pediatric patients and is without an exact etiology. Extensive evaluation of the increased alkaline phosphatase levels can be costly. A “wait and see” approach using minimal further testing can avoid unnecessary costly and potentially harmful diagnostic evaluations.

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