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Research in Pediatrics & Neonatology

Derangements of Sodium Homeostasis in Acute Infantile Diarrhea

*Corresponding author: Ismail E Haffejee, MBBCh, FCP(Paed), MD, FCFP(SA), Honorary Professor and Sessional Consultant, Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZuluNatal, Durban, South Africa

Submission: October 06, 2017; Published: May 09, 2018

ISSN : 2576-9200
Volume2 Issue1


The majority of infants with acute diarrhea have isonatraemic dehydration, where the serum sodium (Na) concentration is within the normal range of 135 to 150 mEq/L. They respond well to both oral and intravenous (IV) rehydration, the latter usually as halfstrength Darrow’s solution which has a Na concentration of 65 mEq/L. Intravenous solutions with higher osmolalities such as Ringer lactate, half-normal saline or even normal saline can safely be used to treat infants showing signs of severe dehydration with or without shock. Clinical signs of dehydration will not be discussed in this paper.

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