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Research in Pediatrics & Neonatology

Agenesis of the Corpus Callosum: Magnetic Resonance Imaging in Antenatal and Postnatal Cases

*Corresponding author: Zoran Milenkovic, General Hospital “Sava Surgery”, Bvl. dr. Zoran Djindjic 91, Nis, Serbia

Submission: September 26, 2017; Published: November 13, 2017

DOI: 10.31031/RPN.2017.01.000506

ISSN : 2576-9200
Volume1 Issue2


Agenesis of the corpus callosum (ACC) is a birth defect manifested by the complete absence of the corpus callosum. The true incidence is dependent on chance because many isolated cases are asymptomatic. It is estimated that the frequency ranges between 0.5 and 70 in 10,000 birth or adult population and is evidently higher in pediatric cases with development anomalies (230 in 10,000 ) or it can reach 2-3 per 100 birth . Genetic factors are considered to be the main cause of ACC. There are no specific signs and symptoms of the malformation. Some of them maybe the result of other associated developmental abnormalities. In cases with isolated ACC, clinical syndromes are divers and vary in the severity of the clinical picture. Magnetic resonance imaging (MRI) is the procedure of choice and is a confirmative method in infants and children as well as in fetuses from about 20 weeks’ gestation. In our series of 4000 MRI explorations in children of different ages, 10 cases harboring ACC were diagnosed, accounting for 0.25%.On the other hand, in 48 pregnant women who were underwent MR investigation between 20 to 36 gestational weeks, another six cases with absence of the corpus callosum were diagnosed.

Keywords: Agenesis of corpus callosum; Epidemiology; Symptomatology; Magnetic resonance imaging

Abbrevations: ACC: Agenesis of the Corpus Callosum; MRI: Magnetic Resonance Imaging

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