Abstract

Background and aims: Many scholars have explored the relationship between carotid atherosclerosis） and vitamin D in patients with type 2 diabetes. Summarize these studies and draw the conclusions.

Methodology/Principal Findings: An electronic search was conducted of several databases, including PubMed, Web of Science, EmBase, Cochrane library, China National Knowledge Infrastructure(CNKI), WANFANG DATA, for papers that describe the association between serum 25-hydroxyvitamin D(25OH-D) related to CAS in patients with type 2 diabetes(T2D).Of these, 6 met our inclusion criteria from which the number of patients.

Result: This meta-analysis indicates that serum 25OH-D concentration is negatively related to CAS in patients with T2D(P=0.000). There is heterogeneity among these studies (SMD=0: z=3.82, p=0.000).

Conclusion: Using new meta-analysis techniques we determined the risk of CAS in patients with T2D is increased low with low serum 25OH-D.

Keywords: Vitamin D; Carotid atherosclerosis; Diabetes; Meta-analysis