1 Department of Physical Therapy, Spain
2 Faculty of Health Sciences, Spain
3 School Clinical Science, Australia
*Corresponding author: Romualdo Castillo Lozano, Lecturer, Department of Physical Therapy, Spain
Submission: January 10, 2019; Published: February 12, 2019
ISSN: 2577-1914 Volume4 Issue3
Background: Recent studies suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors benefit to atherosclerosis-related cardiovascular diseases, but evidence was inconclusive. We aimed to determine the effects of dipeptidyl peptidase-4 inhibitors on Carotid Intima-Media Thickness in type 2 diabetes patients.
Methods: A literature search was conducted via electronic databases. The inclusion criteria were randomized controlled trials (RCTs) comparing DPP-4 inhibitors to placebo or anti-hyperglycaemic agent, study duration of no less than 12 weeks performed in type 2 diabetes patients. The primary outcome was the Intima-Media Thickness of Carotid. Random-effects model were applied to data synthesis.
Results: Five trials enrolling 762 and 761 patients for DPP-4 inhibitors and placebo or anti hyperglycaemic agent were included. The primary outcome of this meta-analysis was mean intima media thickness common carotid artery (mean-IMT-CCA) and left maximum intima media thickness of the common carotid artery (max-left-IMT-CCA). There were no obvious differences in mean-IMT-CCA (SMD: -0.2466, 95%CI [-0.6052, 0.1120], P=0.1777) over 12 months. And that’s the same for 24 months (SMD: -0.5249, 95%CI [-1.1492, 0.0994], P=0.0994). There was no significant difference between DPP-4 Inhibitors and placebo or anti hyperglycemic agent in max-left-IMT-CCA, (SMD:0.2217, 95%CI [-0.2602, 0.7035], P=0.3673). And remained same over 24 months (SMD:0.1064, 95%CI [-0.3498, 0.5627], P=0.6475).
Conclusion: There is no significant decrease on Carotid Intima-Media Thickness after DPP-4 inhibitors treatment over 12 and 24 weeks.
Keywords: Prevention and health promotion models; Childhood and adolescence