Research & Investigations in Sports Medicine

Brain Derived Neurotrophic Factor and Exercise

Submission: February 26, 2018; Published: March 28, 2018

DOI: 10.31031/RISM.2018.02.000537

ISSN: 2577-1914
Volume2 Issue3


Brain-derived neurotrophic factor (BDNF), a dimeric protein found throughout the brain, promotes the survival of nerve cells by playing a role in the growth, maturation, and maintenance of cells [1]. Along with supporting the survival of existing neurons, BDNF encourages differentiation and growth of new neurons and synapses [2,3]. In the brain the hippocampus, cortex, and basal forebrain, which are vital to learning, memory, and higher thinking, are all locations where BDNF is active [4]. A number of stimuli have been found to increase BDNF gene regulation including light in the visual cortex, osmotic in the hypothalamus, electrical in the hippocampus, and exercise in the hippocampus [5].

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