Abstract

Background: While the discussion of allowing preimplantation genetic testing (PGT) with in vitro fertilization (IVF) to be utilized for selecting against disease traits is currently widely accepted, there is not yet a consensus regarding selection for an embryo with disease, or the high likelihood of developing disease. The use of PGT for disease selection is an ethical predicament that has not yet reached a unanimous consensus. The primary objective is to discuss arguments for and against the use of PGT for disease.

Main body: This article discusses arguments for and against the use of PGT for selecting for disease traits. Arguments against this practice include the principle of procreative beneficence and increased utilization of resources. Arguments for this practice include the principle of procreative autonomy, decreased risk of stigmatization, positive social impact, risk reduction methods, and the hope for future medical advancements.

Conclusion: There are multiple factors that must be considered before allowing parents to select for an embryo with disease, or high likelihood of developing disease, as this may result in serious implications for the child and society. It is imperative to keep in mind the balance between harm reduction and eugenics, as well as the potential impacts of prohibiting parents from choosing an embryo with a high probability of disease

Keywords:Genetic selection;Ethics; PGT; IVF;Reproductive medicine;Genetics;Genetic disorders;Disease traits;Infertility.