1Department of Urology, University of Turin, Italy
2Department of Urology, Guarnieri Hospital, Italy
3Department of Urology, Leonardo Da Vinci Hospital, Italy
4Universita Degli Studi di Firenze, Urology, Italy
5Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy
6Department of Urology, Santa Maria Annunziata Hospital, Italy
*Corresponding author: Francesca Pisano, MD, Department of Urology, City of Health and Science-Molinette Hospital, University of Turin, Corso Bramante 88, 10126 Torino, Italy
Submission: February 22, 2018;Published: September 10, 2018
ISSN: 2640-9666Volume2 Issue5
Introduction: The aim of this study was to compare the association of a POTABA based oral compound (PeironiMEV®) with a penile extender (Andropenis®) stretching protocol to Verapamil injections in the treatment of Peyronie’s disease (PD).
Materials and methods: Patients with PD naive to any treatment were enrolled and randomized: Andropenis 8 hours per day plus PeironiMEV 2 tablets/die for 6 months (arm 1); Intralesional Verapamil 5mg/2ml every two weeks for 6 months (arm 2). Patients were evaluated at 3, 6, 12 and 24 months after baseline. Plaque size, curvature degree and penile lenght were recorded at each visit during the follow-up. Functional results were assessed through: Erectile Function (EF) domain score of the International Index of Sexual Function (IIEF), Sexual Encounter Profile (SEP 2) and VAS score.
Results: 40 patients were enrolled. At 12 months, VAS and EF domains of IIEF improvement was significantly higher in arm 1 (p< 0.001). In both arms penile curvature showed a significant reduction (p< 0.001) at 12 months follow up. Penile flaccid and stretched length had a trend to improvement in arm 1 (p 0.087 and 0.078 respectively).
Conclusion: PeironiMEV plus penile stretching impacted on patient erectile function. Moreover, it demonstrated to be more effective than verapamil injections in pain control.
Keywords: Peyronie disease; Penile extender; Conservative treatments; Verapamile injection; Penile curvature