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Psychology and Psychotherapy: Research Study

Role of Deep Brain Stimulation in Treatment Resistant Depression: A Review Article

Submission: April 19, 2021;Published: April 30, 2021

DOI: 10.31031/PPRS.2021.04.000598

ISSN: 2639-0612
Volume4 Issue5


Neuromodulation has been used in Treatment-Resistant Depression (TRD) as a presumed intervention targeting diverse brain regions however, antidepressant properties of DBS for TRD in latest clinical trials are still under debate. We review the main putative neuroanatomical targets of DBS applied for the treatment of intractable TRD in this paper. Different researches imply that stimulation parameters and neuroanatomical locations could influence DBS-related antidepressant effects. Among different neuromodulatory targets that have been studied, DBS in the neuroanatomical structures of the Subcallosal Cingulate Gyrus (SCG), Anterior Limb of Internal Capsule (ALIC), Ventral Capsule/Ventral Septum (VC/VS), Medial Forebrain Bundle (MFB), and Nucleus Accumbans (NAcc) yielded more reliable antidepressant success rates in cases with TRD. Nonetheless, more well-designed randomized double-blind, controlled trials are necessary to entirely evaluate the efficiency, safety and compatibility of these DBS targets for the management of TRD.

Keywords: Depression; Neuromudulation; Subsingular gyrus; Medial forebrain bundle

Abbreviations: TRD: Treatment-Resistant Depression; SCG: Subcallosal Cingulate Gyrus; ALIC: Anterior Limb of Internal Capsule; VC/VS: Ventral Capsule/Ventral Septum; MFB: Medial Forebrain Bundle; NAcc: Nucleus Accumbans; DBS: Deep Brain Stimulation; PD: Parkinson’s Disease; TRD: Treatment-Resistant Depression; LHb: Lateral Habenula; ITP: Inferior Thalamic Peduncle; TRI: Treatment of Intractable; ACC: Anterior Cingulate Cortex; RSE: Retrosplenial Cingulate Cortex; AC: Anterior Commissure

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