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Abstract

Novel Techniques in Nutrition and Food Science

On The Effectiveness of Probiotic as Treatment Strategy of Autism

  • Open or Close Afaf El-Ansary1-4* and Naima Zayed4

    1 Central laboratory, Female Centre for Scientific and Medical Studies, King Saud University, Saudi Arabia

    2 Autism Research and Treatment Centre, Riyadh, Saudi Arabia

    3 Member in Council for Nutritional and Environmental Medicine (CONEM) Norway and Head of CONEM, Child Brain Research Group, Saudi Arabia

    4 Therapeutic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

    *Corresponding author: Afaf El-Ansary, Central laboratory, Female Centre for Scientific and Medical Studies, Autism Research and Treatment Centre, Riyadh, Member in Council for Nutritional and Environmental Medicine (CONEM) Norway and Head of CONEM Saudi Child Brain Research Group,King Saud University, Saudi Arabia

Submission: March 01, 2018; Published: April 17, 2018

DOI: 10.31031/NTNF.2018.01.000520

ISSN 2640-9208
Volume1 Issue4

Abstract

The gut micro biota and its metabolites play important roles in the body physiology, including the brain. Dysbiosis or micro biota alterations are involved in numerous pathologies, including neuro developmental disorders. The frequent occurrence of gastrointestinal symptoms in autistic patients could suggest the possible involvement of impaired gut micro biota as etiological mechanism in autism. Up to our understanding of the etiological mechanisms of autism through our clinical and experimental research, it was interesting to relate altered gut micro biota to neuro inflammation, oxidative stress, heavy metal toxicity, autoimmunity, and glutamate excitotoxicity to clarify the possibility of targeting gut micro biota to ameliorate these contributed pathologic signaling and thus treat autism.

Abbreviations: SCFAs: Short Chain Fatty Acids; LPS: Lip Polysaccharides; TNF-α: Tumor Necrosis Factor-α; IL-6: Inter leukin-6; TNF-α: Tumor Necrosis Factor-α; BBB: Blood Brain Barrier; GABA: Gamma Amino Butyric Acid; GI: Gastro Intestinal

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