Abstract

The gut micro biota and its metabolites play important roles in the body physiology, including the brain. Dysbiosis or micro biota alterations are involved in numerous pathologies, including neuro developmental disorders. The frequent occurrence of gastrointestinal symptoms in autistic patients could suggest the possible involvement of impaired gut micro biota as etiological mechanism in autism. Up to our understanding of the etiological mechanisms of autism through our clinical and experimental research, it was interesting to relate altered gut micro biota to neuro inflammation, oxidative stress, heavy metal toxicity, autoimmunity, and glutamate excitotoxicity to clarify the possibility of targeting gut micro biota to ameliorate these contributed pathologic signaling and thus treat autism.

Abbreviations: SCFAs: Short Chain Fatty Acids; LPS: Lip Polysaccharides; TNF-α: Tumor Necrosis Factor-α; IL-6: Inter leukin-6; TNF-α: Tumor Necrosis Factor-α; BBB: Blood Brain Barrier; GABA: Gamma Amino Butyric Acid; GI: Gastro Intestinal