Abstract

Satureja hortensis (Summer savory) from Lamiaceae (Labiatae) family is valuable by its rich existence of essential oil. Taking into account several pharmacological effects of mentioned genus essential oil’s compounds, it was investigated the Armenian flora Satureja hortensis essential oil chemical composition, obtained pharmaceutical forms and studied anti-inflammatory, antinociceptive and wound healing activities. Satureja hortensis essential oil chemical composition analysis was carried out by Gas Chromatography-Mass Spectroscopy (GC-MS) method. Antimicrobial effects of the essential oil were studied by disc-diffusion assay. The evaluation indicator for antimicrobial activity was the inhibited zone diameter in the Petri plates. The mentioned oil antinociceptive and anti-inflammatory activities have been estimated correspondingly in the “tail-flick” and xylene induced acute ears edema test of rats’ experimental model. The rats were pretreated with 20, 50 and 100mg/kg doses. The regeneration ability of the ointment from essential oil of Savory leaves under the condition of thermal burn has been studied. The obtained results demonstrate, that Armenian origin Satureja hortensis essential oil contain rich number of monoterpenes and appear expressed anti-inflammatory, antinociceptive, antimicrobial and wound healing activity. The latter is explained by inhibition of some pathogenic microbes’ growth in the wound such as Proteus mirabilis, Klebsiella, Escherichia coli, as well as wound surface decrease during treatment with ointment obtained from Satureja hortensis leaves essential oil. These results indicate that the investigated plant essential oil could be a beneficial source for the development of new agents with the mentioned activity.

Keywords: Satureja hortensis; Essential oil; Anti-inflammatory; Antinociceptive; Antimicrobial activity