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Saccharomyces cerevisiae as A Fusion Inhibitor of Sars-Cov-2

Submission: February 05, 2021;Published: March 02, 2021


SARS-CoV-2 interacts with prokaryotic translation elongation factors (eEFs), predominantly eEF1A. This connection occurs at the intracellular level, when the virus is linked to ribosomes, necessary for viral replication. The fungus Saccharomyces cerevisiae has an abundance of eEF1A protein, and its dietary supplementation can increase serum protein levels, which, by binding to viruses circulating in the blood, prevent the entry of these cells, thus preventing viral replication; in addition, exposes the virus to the body’s humoral immune system. Supplementation through the diet of the fungus Saccharomyces cerevisiae would work as a fusion inhibitor drug, a mechanism of action of some antivirals.

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