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Correlation Between Total Ischemic Time with Creatinin Level and Urine Production in Kidney Transplant : A Single Centre Report

Submission: June 05, 2019;Published: June 10, 2019


Background: Kidney transplantation is acknowledged as a major advance of modern medicine which provides high-quality life years to patients with irreversible kidney failure (end-stage renal disease, ESRD) worldwide. The first kidney transplantation in Semarang underwent at Telogorejo Hospital in 1985. Dr. Kariadi Hospital nowadays, kidney transplantation had done 28 times since January 2014 until September 2018. Kidney ischemic time is one of the important factor which can affect the outcome of kidney transplantation. The prolonged ischemic of the graft can be related with the effect transplantation. This study is aimed to evaluate the influence of total ischemic time with the outcome of kidney transplantation in Dr. Kariadi Hospital Semarang.

Material and Methods: This is an observasional, cross sectional study. The data was collected from medical record. The subject of this study were all patients who underwent kidney transplantation that recorded in medical record from January 2014 until December 2018 and the level of creatinin dan urin production before and after transplantation was documented. There are 28 patient who include in inclusion criteria. The results of the study will be tabulated and statistical calculations are performed using SPSS 23.0. The relationship is declared meaningful if p = 0.05 is obtained.

Result: From the analysis of the research that has been done using Pearson correlation test and hypothesis test Wilcoxon and it was found that there was a relationship between ischemic time and a decrease in creatinine level from r = -0.4489 with a value of p = 0.008. From the analysis of the research that has been done, there is a relationship between ischemic time and urine production after transplantation with a value of r = -0.562 and a value of p = 0.002.

Conclusion: From the results of this study there is a strong correlation between the length of total ischemic time with a decrease in creatinine and urine production which means that the longer ischemic time the lower the decrease in creatinine levels and the less urine production.

Keywords: Total ischemic time; Creatinin level; Urine production; Kidney transplantation

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