Department of Pharmacology and Toxicology, German University in Cairo, Egypt
*Corresponding author: Hassan Adwan, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo GUC, Main Entrance Al Tagamoa Al Khames, New Cairo 11835, Egypt
Submission: July 19, 2018; Published: August 14, 2018
As Personalized Medicine tailored the field of precision oncology, many challenges have been arising to fulfill the dream of a full personalized health integrated system in cancer therapy. Personalized oncology has been addressed through the past decades in multiple disease and various stages using high throughput technology. This review gives hand on recent advances of personalized oncology in several cancer disease models including leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and prostate cancer. Moreover, the review enumerates technology-based assessment of personalized biomarkers, including chip micro-array, organ on chip, and next generation sequencing. Meanwhile addressing challenges faced in implementing true personalized health cancer in oncology setting, this review focuses on bridging the gap between omics data analytics and epidemiology to overcome the true challenge of direct application.
Keywords: Personalized medicine; Precision oncology; Pharmacogenomics; Pharmacometabolomics; Pharmacomicrobiomics; Pharmacometrics; Pharmacokinetics; Clinical epidemiology