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Abstract

Novel Approaches in Cancer Study

Significance of Trace Element Quantities in Osteomyelitis and Osteosarcoma

  • Open or Close Vladimir Zaichick1* and Sofia Zaichick1,2

    1Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia

    1Laboratory of Dr Gabriela Caraveo Piso, Feinberg School of Medicine Northwestern University, USA

    *Corresponding author: Dr. V Zaichick, Medical Radiological Research Centre, Korolyev St.4, Obninsk 249036, Kaluga Region, Russia

Submission: February 10, 2018; Published: February 26, 2018

DOI: 10.31031/NACS.2018.01.000510

ISSN:2637-773X
Volume1 Issue2

Abstract

To clarify the role of trace elements (TE) in the etiology and the pathogenesis of osteomyelitis (OM) and osteosarcoma (OS), a nondestructive neutron activation analysis were performed. The Ag, Co, Cr, Fe, Hg, Rb, Sb, Se, and Zn contents were measured in three groups of samples: normal bone samples from 27 persons with intact bone, and also in samples, obtained from open biopsies or after operation of 10 patients with OM and 27 patients with OS. The difference in the results between TE contents in the three groups was evaluated by the parametric Student’s t-test and non-parametric Wilcoxon-Mann-Whitney U-test. In the OM tissue the mean contents of Co, Cr, Fe, Se, and Zn are respectively 1.8, 1.7, 1.8, 1.7, and 1.5 times higher than those in normal bone tissues In the OS tissue the mean mass fractions of Co, Cr, Fe, Sb, Se, and Zn are respectively 4.6, 2.0, 4.8 2.4, 11.0, and 2.4 times higher while the mean mass fraction of Rb is more than 40% lower than in normal bone tissues. In the OS tissue the mean mass fractions of Co, Fe, Se, and Zn are significantly higher (2.6, 2.6, 6.2, and 1.6 times, respectively) and the mean mass fraction of Rb is more than 2 times lower than in inflamed bone. In addition, many inter-correlations between TE contents found in the control group were no longer evident in the inflamed and tumor transformed bone. Thus, considerable changes in TE content and their relationships were found in OM and OS and possible causes and effects of these alterations are discussed.

Keywords: Trace elements; Human bone; Osteomyelitis; Osteosarcoma; Neutron activation analysis

Abbreviation OM: Osteomyelitis; OS: Osteosarcoma; TE: Trace Elements; INAA: Instrumental Neutron Activation Analysis; INAA-LLR: INAA With High Resolution Spectrometry Of Long-Lived Radionuclides; BSS: Biological Synthetic Standards; CRM: Certified Reference Material; SRM: Standard Reference Material; ROS: Reactive Oxygen Species

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