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Novel Approaches in Cancer Study

Current Targets of Immune Suppression in Tumor Microenvironment

  • Open or Close Kwei-Yan Liu1, Li-Ting Wang1 and Shih-Hsien Hsu1,2*

    1Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan

    2Department of Medical Research, Kaohsiung Medical University Hospital, Taiwan

    *Corresponding author: Shih-Hsien Hsu, Graduate Institute of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan

Submission: November 11, 2017; Published: December 08, 2017

DOI: 10.31031/NACS.2017.01.000505

Volume1 Issue1


In the past years, scientists have discovered tumor microenvironment (TME) as a comfort zone of cancer cells. Efforts are being globally made to disrupt this comfort zone of cancer cells. However, a despiteseveral effort, the complete blockage of tumor progression has not been achieved because of unclear cellular and molecular mechanisms of TME crosstalk. Cancer immunotherapy is one of the promising therapies that have the ability to disrupt TME by restoring the immune attack on malignant cells [1]. However, positive outcomes of immunotherapy have been reported only in few patients, suggesting a need for the unmasking of regulatory mechanisms.

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